C-Reactive Protein on Nitric Oxide Bioavailability Inflammation and Endothelial Function: Direct Vascular Effects of Human
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Copyright © 2005 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/01.CIR.0000159336.31613.31 2005;111;1530-1536 Circulation Patrick Vallance and Aroon D. Hingorani Stidwill, Mervyn Singer, John E. Deanfield, Raymond J. MacAllister, Mark B. Pepys, Brian R. Clapp, Gideon M. Hirschfield, Clare Storry, J. Ruth Gallimore, Ray P. C-Reactive Protein on Nitric Oxide Bioavailability Inflammation and Endothelial Function: Direct Vascular Effects of Human http://circ.ahajournals.org/cgi/content/full/111/12/1530 located on the World Wide Web at: The online version of this article, along with updated information and services, is
منابع مشابه
Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability.
BACKGROUND Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated. We therefore investigated the direct effect of CRP on vascular reactivity. METHODS AND RESULTS The effects of isolated, pure human CRP on vasoreactivity and prote...
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C-reactive protein (CRP), a pentraxin synthesized in the liver, is a highly conserved pentameric plasma protein that participates in the systemic response to inflammation. In humans, plasma levels of CRPmay rise rapidly and markedly (>1000-fold) after an acute inflammatory stimulus and presumably contribute to host defence [1]. On the other hand, although CRP may exert pleiotropic effects, both...
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Background Inflammation is important in the development, progression and acute complications of atherosclerosis. Increased levels of inflammatory markers in humans predict the occurrence of future atherothrombotic events. Recognised risk factors for atherosclerosis have been shown to cause endothelial dysfunction, characterised by impaired endothelial nitric oxide-dependent vasodilator response...
متن کاملInflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress.
OBJECTIVES Our aim was to investigate mechanisms of inflammation-induced endothelial dysfunction in humans. METHODS Endothelial function in twenty-one healthy human volunteers was measured using forearm venous plethysmography before and 8 h after administration of typhoid vaccination to generate an inflammatory response. Basal and stimulated endothelial nitric oxide (NO) bioavailability was a...
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تاریخ انتشار 2005